AC PRU01333; DC Domain; TR PROSITE; PS51989; COV_NSP2_N; 1; level=0 XX Names: Coronavirus (CoV) Nsp2 N-terminal domain Function: The Nsp2 N-terminal domain contains ten alpha-helices and fourteen beta-sheets with three zinc fingers (ZnFs), belonging to the C2H2, C4, and C2HC types, respectively. The three zinc fingers are not involved in binding nucleic acids directly but may play other unknown functions. The interaction of Nsp2 and nucleic acid is mainly dependent on a large positively charged region on the electrostatic surface of the Nsp2 N-terminal domain. XX CC -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family. XX case or or GO GO:0046872; F:metal ion binding GO GO:0008270; F:zinc ion binding XX KW Metal-binding KW Zinc end case KW Zinc-finger XX FT From: PS51989 FT DOMAIN from..to FT /note="CoV Nsp2 N-terminal #" FT REGION 18..44 FT /note="C2H2" FT Group: 1 FT BINDING 18 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#1" FT Group: 1; Condition: C FT BINDING 39 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#1" FT Group: 1; Condition: C FT BINDING 42 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#1" FT Group: 1; Condition: H FT BINDING 44 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#1" FT Group: 1; Condition: H FT REGION 132..153 FT /note="C4" FT Group: 2 FT BINDING 132 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#2" FT Group: 2; Condition: C FT BINDING 135 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#2" FT Group: 2; Condition: C FT BINDING 151 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#2" FT Group: 2; Condition: C FT BINDING 153 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#2" FT Group: 2; Condition: C FT REGION 176..213 FT /note="C2HC" FT Group: 3 FT BINDING 176 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#3" FT Group: 3; Condition: C FT BINDING 179 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#3" FT Group: 3; Condition: C FT BINDING 188 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#3" FT Group: 3; Condition: H FT BINDING 213 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="#3" FT Group: 3; Condition: C XX Chop: Nter=0; Cter=0; Size: 230-290; Related: None; Repeats: 1; Topology: Undefined; Example: P0C6U7; Scope: Viruses; Orthocoronavirinae Comments: None; XX # Revision 1.3 2022/11/19 //