AC   PRU01351;
DC   Domain;
TR   PROSITE; PS52007; PADR1; 1; level=0
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Names: PADR1 zinc-binding domain
Function: The PADR1 zinc-binding domain is involved in protein-protein
 interactions that orchestrate PARP-1 activation and are critical to the DNA-
 dependent stimulation of PARP-1. It relays the DNA binding signal from the
 first two zinc fingers to the catalytic C terminus by helping to establish
 the active form of the enzyme.
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CC   -!- SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Chromosome.
CC       Note=Localizes to sites of DNA damage.
CC   -!- SIMILARITY: Belongs to the ARTD/PARP family.
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GO   GO:0005730; C:nucleolus
GO   GO:0070212; P:protein poly-ADP-ribosylation
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
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KW   Metal-binding
KW   Zinc
end case
KW   ADP-ribosylation
KW   Nucleus
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FT   From: PS52007
FT   DOMAIN          from..to
FT                   /note="PADR1 zinc-binding #"
FT   REGION          66..108
FT                   /note="Zinc ribbon #"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         74
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         87
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         97
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
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Chop: Nter=0; Cter=0;
Size: 130-155;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q9N4H4;
Scope:
 Eukaryota
Comments: None;
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# Revision 1.2 2022/11/19
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