AC   PRU01362;
DC   Domain;
TR   PROSITE; PS52018; DART; 1; level=0
XX
Names: DNA ADP-ribosyl transferase (DarT) domain
Function: The bacterial DNA ADP-ribosyl transferase (DarT) protein is a toxin
 that has been shown to transfer ADP-ribose from NAD(+) onto thymidine bases
 present in single-stranded DNA (ssDNA) specifically at the four-base motif
 TNTC, and to have no activity on RNA or protein targets.
XX
case <FTGroup:1>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a thymidine in DNA + NAD(+) = an N-(ADP-alpha-D-ribosyl)-
CC         thymidine in DNA + nicotinamide + H(+); Xref=Rhea:RHEA:71651,
CC         Rhea:RHEA-COMP:13556, Rhea:RHEA-COMP:18051,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:137386, ChEBI:CHEBI:191199;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71652;
end case
CC   -!- SIMILARITY: Belongs to the DarT ADP-ribosyltransferase family.
XX
GO   GO:0003677; F:DNA binding
case <FTGroup:1>
GO   GO:0016779; F:nucleotidyltransferase activity
GO   GO:0016757; F:glycosyltransferase activity
XX
KW   Glycosyltransferase
KW   Nucleotidyltransferase
KW   Transferase
end case
KW   DNA-binding
KW   Toxin-antitoxin system
XX
FT   From: PS52018
FT   DOMAIN          from..to
FT                   /note="DarT"
FT   BINDING         5..7
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Group: 1
case <FTGroup:1>
FT   BINDING         14
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: G
FT   BINDING         22
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: L
end case
FT   ACT_SITE        44
FT                   /note="Proton acceptor"
FT   Group: 1; Condition: R
FT   BINDING         44
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Group: 1
FT   ACT_SITE        141
FT   Group: 1; Condition: E
XX
Chop: Nter=0; Cter=0;
Size: 192-205;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: A0A0B0SG80;
Scope:
 Bacteria
Comments: None;
XX
# Version: 3
# Last updated date: 2024-09-03
# Created date: 2023-02-21
//