AC   PRU01368;
DC   Domain;
TR   PROSITE; PS52024; GL_AHV; 1; level=0
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Names: Alphaherpesvirus glycoprotein L (gL) domain
Function: Two glycoprotein complexes are conserved throughout the three
 herpesvirus subfamilies: the trimeric glycoprotein B (gB) that functions as a
 membrane fusogen and the heterodimeric glycoprotein H/glycoprotein L (gH/gL),
 the role of which is less clearly defined. The intrinsic structural
 plasticity of gH/gL enables it to function as a signal integration machine
 that can accept diverse regulatory inputs and convert them into a "trigger"
 signal that activates the fusogenic ability of gB.
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DE   + AltName: Full=Envelope glycoprotein L;
DE            Short=gL;
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CC   -!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is
CC       required for the fusion of viral and plasma membranes leading to
CC       virus entry into the host cell. Acts as a functional inhibitor of
CC       gH and maintains gH in an inhibited form. Upon binding to host
CC       integrins, gL dissociates from gH leading to activation of the
CC       viral fusion glycoproteins gB and gH.
CC   -!- SUBUNIT: Interacts with glycoprotein H (gH); this interaction is
CC       necessary for the correct processing and cell surface expression
CC       of gH. The heterodimer gH/gL seems to interact with gB trimers
CC       during fusion.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Peripheral membrane
CC       protein; Extracellular side. Host cell membrane; Peripheral
CC       membrane protein; Extracellular side. Host Golgi apparatus, host
CC       trans-Golgi network. Note=gL associates with the extravirion
CC       surface through its binding to gH. During virion morphogenesis,
CC       this protein probably accumulates in the host trans-Golgi where
CC       secondary envelopment occurs.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein L (gL) family.
CC       Alphaherpesvirinae gL subfamily.
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GO   GO:0044177; C:host cell Golgi apparatus
GO   GO:0055036; C:virion membrane
GO   GO:0016020; C:membrane
GO   GO:0046718; P:symbiont entry into host cell
GO   GO:0020002; C:host cell plasma membrane
GO   GO:0019064; P:fusion of virus membrane with host plasma membrane
GO   GO:0019031; C:viral envelope
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KW   Fusion of virus membrane with host cell membrane
KW   Fusion of virus membrane with host membrane
KW   Glycoprotein
KW   Host Golgi apparatus
KW   Host cell membrane
KW   Host membrane
KW   Membrane
KW   Viral envelope protein
KW   Viral penetration into host cytoplasm
KW   Virion
KW   Virus entry into host cell
case <FTTag:disulf>
KW   Disulfide bond
end case
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FT   From: PS52024
FT   DOMAIN          from..to
FT                   /note="gL alphaherpesvirus-type #"
FT   DISULFID        22..53
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        126..138
FT   Tag: disulf; Condition: C-x*-C
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Chop: Nter=0; Cter=0;
Size: 107-179;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P52510;
Scope:
 Viruses; Alphaherpesvirinae
Comments: None;
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# Revision 1.2 2024/03/01
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