AC PRU01374; DC Domain; TR PROSITE; PS52030; SMDRR; 1; level=0 XX Names: Streptococcal M proteins D repeat Function: M proteins belong to a family of fibrous streptococcal surface proteins which represent major virulence factors due to their antiphagocytic activities. All M proteins share a common framework that includes a conserved signal peptide, a hypervariable amino terminus, a less variable central domain, and a highly conserved C-terminus. A number of repeat sequences (A, B, C and D repeats) follow the hypervariable region. Sequence conservation increases from the A repeats to D repeats. XX CC -!- SUBCELLULAR LOCATION: Secreted, cell wall; Peptidoglycan-anchor. CC -!- SIMILARITY: Belongs to the M protein family. XX GO GO:0005576; C:extracellular region XX KW Cell wall KW Peptidoglycan-anchor KW Secreted XX FT From: PS52030 FT REPEAT from..6 FT /note="D #" FT REPEAT 7..12 FT /note="D #" FT REPEAT 15..20 FT /note="D #" FT REPEAT 22..to FT /note="D #" XX Chop: Nter=0; Cter=0; Size: 27-27; Related: None; Repeats: 1; Topology: Undefined; Example: Q5X9Q9; Scope: Bacteria; Streptococcus Comments: None; XX # Revision 1.1 2023/07/05 //