AC   PRU01378;
DC   Domain;
TR   PROSITE; PS52034; PEPTIDASE_M32; 1; level=0
XX
Names: Peptidase family M32 domain
Function: The M32 family of Zn-dependent metallocarboxypeptidases (MCPs)
 contains a group of hydrolases, which although being broadly distributed
 among prokaryotic organisms, are only present in a few eukaryotes including
 some green algae and trypanosomatids.
XX
case <FTTag:act_site> and <FTGroup:1>
DE   + AltName: EC=3.4.17.19;
end case
XX
case <FTTag:act_site> and <FTGroup:1>
CC   -!- CATALYTIC ACTIVITY: Reaction=Release of a C-terminal amino acid
CC       with broad specificity, except for -Pro.; EC=3.4.17.19;
end case
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=CHEBI:60240;
CC       Note=Binds 1 divalent metal cation per subunit.
end case
CC   -!- SIMILARITY: Belongs to the peptidase M32 family.
XX
case <FTTag:act_site> and <FTGroup:1>
GO   GO:0004181; F:metallocarboxypeptidase activity
GO   GO:0006508; P:proteolysis
XX
KW   Carboxypeptidase
KW   Hydrolase
KW   Metalloprotease
KW   Protease
end case
case <FTGroup:1>
KW   Metal-binding
end case
XX
FT   From: PS52034
FT   DOMAIN          from..to
FT                   /note="Peptidase M32 #"
FT   MOTIF           232..234
FT                   /note="HPF #"
FT   Condition: H-P-F
FT   MOTIF           241..245
FT                   /note="DXRXT #"
FT   Condition: D-x-R-x-T
FT   MOTIF           262..266
FT                   /note="HEXXH #"
FT   Condition: H-E-x(2)-H
FT   MOTIF           291..294
FT                   /note="HES/GQ #"
FT   Condition: H-E-[SG]-Q
FT   MOTIF           344..349
FT                   /note="I/NRXXA/SD #"
FT   Condition: [IN]-R-x(2)-[AS]-D
FT   MOTIF           399..406
FT                   /note="GXXQDXHW #"
FT   Condition: G-x(2)-Q-D-x-H-W
FT   ACT_SITE        263
FT                   /note="Proton donor/acceptor"
FT   Tag: act_site; Condition: E
FT   BINDING         262
FT                   /ligand="a divalent metal cation #"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         266
FT                   /ligand="a divalent metal cation #"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         292
FT                   /ligand="a divalent metal cation #"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: E
XX
Chop: Nter=0; Cter=0;
Size: 494-504;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P50848;
Scope:
 Bacteria
 Archaea; Pyrococcus
Comments: None;
XX
# Revision 1.2 2023/08/08
//