AC   PRU01380;
DC   Domain;
TR   PROSITE; PS52036; ZF_RG_N; 1; level=0
XX
Names: Zinc finger reverse gyrase N-terminal-type
Function: Reverse gyrase (RG) is an ATP-dependent topoisomerase that is only
 found in archaeal and bacterial hyperthermophiles (above 80 degre C) and
 thermophiles (65-80 degre C). RGs share a modular structure with an N-
 terminal cysteine-rich region (a zinc finger) preceding a helicase domain
 that is followed by a C-terminal topoisomerase domain. The helicase domain is
 subdivided into H1 and H2 domains that are flexibly linked. Some RG
 topoisomerase domains also include a cysteine-rich region that has been
 proposed to form a second zinc finger. The two zinc-finger motifs are found
 to be important to the structure stability maintenance of RG at high
 temperature. The N-terminal zinc finger firmly attaches the H1 domain to the
 topoisomerase domain and may contribute to double-strand DNA (dsDNA) binding.
XX
case (<Feature:PS52036:11=[CH]> and <Feature:PS52036:14=[CH]> and <Feature:PS52036:29=[CH]> and <Feature:PS52036:32=[CH]>)
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
XX
GO   GO:0046872; F:metal ion binding
GO   GO:0008270; F:zinc ion binding
XX
KW   Metal-binding
KW   Zinc
end case
KW   Zinc-finger
XX
FT   From: PS52036
case (<Feature:PS52036:11=[C]> and <Feature:PS52036:14=[C]> and <Feature:PS52036:29=[C]> and <Feature:PS52036:32=[C]>)
FT   ZN_FING         from..to
FT                   /note="RG N-terminal-type #"
else case (<Feature:PS52036:11=[CH]> and <Feature:PS52036:14=[CH]> and <Feature:PS52036:29=[CH]> and <Feature:PS52036:32=[CH]>)
FT   ZN_FING         from..to
FT                   /note="RG N-terminal-type #; atypical"
else
FT   ZN_FING         from..to
FT                   /note="RG N-terminal-type #; degenerate"
end case
FT   BINDING         11
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         14
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         29
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         32
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
XX
Chop: Nter=0; Cter=0;
Size: 37-47;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P0DW67;
Scope:
 Archaea
 Bacteria
Comments: None;
XX
# Revision 1.1 2023/09/13
//