AC   PRU01382;
DC   Domain;
TR   PROSITE; PS52038; TOPO_IB_2; 1; level=0
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Names: Topoisomerase (Topo) IB-type catalytic domain
Function: The RKKRH/N "catalytic pentad", conserved in all members of the topo
 IB family, catalyzes the attack of the active site tyrosine nucleophile on
 the scissile phosphodiester.
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case <FTTag:act_site>
DE   + AltName: EC=5.6.2.1;
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CC   -!- CATALYTIC ACTIVITY: Reaction=ATP-independent breakage of single-
CC       stranded DNA, followed by passage and rejoining.; EC=5.6.2.1;
CC   -!- SIMILARITY: Belongs to the type IB topoisomerase family.
XX
DR   PROSITE; PS00176; TOPO_IB_1; 1; trigger=no
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GO   GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO   GO:0006265; P:DNA topological change
end case
GO   GO:0003677; F:DNA binding
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KW   DNA-binding
case <FTTag:act_site>
KW   Isomerase
KW   Topoisomerase
end case
XX
FT   From: PS52038
FT   DOMAIN          from..to
FT                   /note="Topo IB-type catalytic #"
FT   ACT_SITE        262
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT   Tag: act_site; Condition: Y
XX
Chop: Nter=0; Cter=0;
Size: 238-475;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q8R4U6;
Scope:
 Eukaryota
 Viruses; Nucleocytoviricota
Comments: None;
XX
# Revision 1.1 2023/09/19
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