AC   PRU01383;
DC   Domain;
TR   PROSITE; PS52039; TOPO_IA_2; 1; level=0
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Names: Topoisomerase (Topo) IA-type catalytic domain
Function: Topo IA form a transient 5'-phospho-tyrosine covalent intermediate
 and release a free 3'-OH strand. The Topo IA-type catalytic domain consisting
 of subdomains III, II and IV exhibits a typical toroidal shape with a central
 hole able to accommodate single-strand or double-strand DNA.
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CC   -!- SIMILARITY: Belongs to the type IA topoisomerase family.
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case <FTTag:act_site>
DR   PROSITE; PS00396; TOPO_IA_1; 1; trigger=no
end case
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GO   GO:0003677; F:DNA binding
case <FTTag:act_site>
GO   GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity
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KW   Isomerase
KW   Topoisomerase
end case
KW   DNA-binding
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FT   From: PS52039
FT   DOMAIN          from..to
FT                   /note="Topo IA-type catalytic #"
FT   ACT_SITE        158
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT   Tag: act_site; Condition: Y
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Chop: Nter=0; Cter=0;
Size: 269-889;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q9NG98;
Scope:
 Bacteria
 Archaea
 Eukaryota
 Viruses; Mimivirus bradfordmassiliense
Comments: None;
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# Revision 1.1 2023/09/28
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