AC   PRU01384;
DC   Domain;
TR   PROSITE; PS52040; TOPO_IIA; 1; level=0
XX
Names: Topoisomerase (Topo) IIA-type catalytic domain
Function: Type IIA enzymes include topoisomerase II (topo II) encoded by both
 eukaryotes and viruses, and DNA gyrase and topoisomerase IV (topo IV) encoded
 by bacteria. The Topo IIA-type catalytic domain containing the active site
 tyrosine involved in the covalent complex with DNA is located on the C-
 terminal region of eukaryal enzymes or on the A-subunit of bacterial enzymes
 (GyrA or ParC for gyrase and Topo IV respectively).
XX
case <FTTag:act_site>
DE   + AltName: EC=5.6.2.2;
CC   -!- CATALYTIC ACTIVITY: Reaction=ATP-dependent breakage, passage and
CC       rejoining of double-stranded DNA.; EC=5.6.2.2;
end case
XX
GO   GO:0003677; F:DNA binding
case <FTTag:act_site>
GO   GO:0006265; P:DNA topological change
XX
KW   Isomerase
KW   Topoisomerase
end case
KW   DNA-binding
XX
FT   From: PS52040
FT   DOMAIN          from..to
FT                   /note="Topo IIA-type catalytic #"
FT   ACT_SITE        93
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT   Tag: act_site; Condition: Y
XX
Chop: Nter=0; Cter=0;
Size: 60-890;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P0C1U9;
Scope:
 Bacteria
 Eukaryota
 Viruses
 Archaea; Haloferacaceae
Comments: None;
XX
# Revision 1.1 2023/10/05
//