AC   PRU01385;
DC   Domain;
TR   PROSITE; PS52041; TOPO_IIB; 1; level=0
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Names: Topoisomerase (Topo) IIB-type catalytic domain
Function: DNA cleavage by topo VI generates two-nucleotide 5'-protruding ends.
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case <FTTag:act_site>
DE   + AltName: EC=5.6.2.2;
CC   -!- CATALYTIC ACTIVITY: Reaction=ATP-dependent breakage, passage and
CC       rejoining of double-stranded DNA.; EC=5.6.2.2;
end case
CC   -!- SIMILARITY: Belongs to the TOP6A family.
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GO   GO:0003677; F:DNA binding
case <FTTag:act_site>
GO   GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
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KW   Isomerase
KW   Topoisomerase
end case
KW   DNA-binding
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FT   From: PS52041
FT   DOMAIN          from..to
FT                   /note="Topo IIA-type catalytic #"
FT   ACT_SITE        95
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT   Tag: act_site; Condition: Y
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Chop: Nter=0; Cter=0;
Size: 92-151;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q9M4A2;
Scope:
 Archaea
 Eukaryota
Comments: None;
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# Revision 1.1 2023/10/13
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