AC   PRU01387;
DC   Domain;
TR   PROSITE; PS50049; THD_2; 1; level=0
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Names: TNF domain
Function: TNF ligands share a common structural motif, the TNF homology domain
 (THD), which binds to cysteine-rich domains (CRDs) of TNF receptors. The THD
 is a 150 amino acid long sequence containing a conserved framework of
 aromatic and hydrophobic residues.
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DR   PROSITE; PS00251; THD_1; 1; trigger=no
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CC   -!- SIMILARITY: Belongs to the tumor necrosis factor family.
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GO   GO:0005164; F:tumor necrosis factor receptor binding
GO   GO:0005125; F:cytokine activity
GO   GO:0005615; C:extracellular space
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KW   Cytokine
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case <FTTag:disulf>
KW   Disulfide bond
end case
FT   From: PS50049
FT   DOMAIN          from..to
FT                   /note="THD #"
FT   DISULFID        12..32
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        12..136
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        62..96
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        75..126
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        96..111
FT   Tag: disulf; Condition: C-x*-C
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Chop: Nter=0; Cter=0;
Size: 131-167;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q3ZDR4;
Scope:
 Eukaryota; Metazoa
Comments: None;
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# Revision 1.1 2024/02/15
//