AC   PRU01389;
DC   Domain;
TR   PROSITE; PS52044; VLRF1; 1; level=0
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Names: Vms1-like release factor 1 (VLRF1) domain
Function: The ANKZF1/Vms1 Vms1-like release factor 1 (VLRF1) domain, which
 acts as a peptidyl-tRNA hydrolase, has a catalytic loop bearing a conserved
 glutamine. In addition to the glutamine in the active site, the VLRF1 domain
 also contains conserved vicinal arginines in the alpha-helix immediately
 following the active-site loop. The cleavage mechanism involves remodelling
 and cleavage of the ribose-phosphate backbone of the tRNA by a tyrosine and
 the GSQ motif.
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CC   -!- DOMAIN: The VLRF1 domain mediates binding to the 60S ribosomal
CC       subunit.
CC   -!- SIMILARITY: Belongs to the ANKZF1/VMS1 family.
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GO   GO:0005737; C:cytoplasm
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KW   Cytoplasm
case <FT:2>
KW   Endonuclease
KW   Hydrolase
KW   Nuclease
end case
FT   From: PS52044
FT   DOMAIN          from..to
FT                   /note="VLRF1 #"
FT   ACT_SITE        44
FT   Condition: Q
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Chop: Nter=0; Cter=0;
Size: 142-161;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q80UU1;
Scope:
 Eukaryota
Comments: None;
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# Revision 1.1 2024/05/30
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