AC   PRU01393;
DC   Domain;
TR   PROSITE; PS52048; UCH_DOMAIN; 1; level=0
XX
Names: Ubiquitin carboxyl-terminal hydrolase (UCH) catalytic domain
Function: Ubiquitin C-terminal hydrolases (UCHs) are deubiquitinating enzymes
 which hydrolyze C-terminal esters and amides of ubiquitin. They have a
 catalytic core domain consisting of about 230 amino acids.
XX
case <FTGroup:1>
DE   + RecName: EC=3.4.19.12;
XX
CC   -!- CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester,
CC       thioester, amide, peptide and isopeptide bonds formed by the C-
CC       terminal Gly of ubiquitin (a 76-residue protein attached to
CC       proteins as an intracellular targeting signal).; EC=3.4.19.12;
end case
CC   -!- SIMILARITY: Belongs to the peptidase C12 family.
XX
case <FTGroup:1>
DR   PROSITE; PS00140; UCH_1; 0-1; trigger=no
XX
GO   GO:0004843; F:cysteine-type deubiquitinase activity
GO   GO:0006511; P:ubiquitin-dependent protein catabolic process
XX
KW   Hydrolase
KW   Protease
KW   Thiol protease
KW   Ubl conjugation pathway
end case
XX
FT   From: PS52048
FT   DOMAIN          from..to
FT                   /note="UCH catalytic #"
FT   ACT_SITE        88
FT                   /note="Nucleophile"
FT   Group: 1; Condition: C
FT   ACT_SITE        163
FT                   /note="Proton donor"
FT   Group: 1; Condition: H
FT   SITE            82
FT                   /note="Transition state stabilizer"
FT   Group: 1; Condition: Q
FT   SITE            178
FT                   /note="Important for enzyme activity"
FT   Group: 1; Condition: D
XX
Chop: Nter=0; Cter=0;
Size: 209-323;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q6SEG5;
Scope:
 Eukaryota
Comments: None;
XX
# Revision 1.3 2024/09/13
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