AC   PRU01398;
DC   Domain;
TR   PROSITE; PS52053; NEL; 1; level=0
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Names: Novel E3 ligase (NEL) domain
Function: The ~300 residue NEL domain bears a cysteine residue that mediates
 transfer of ubiquitin to substrates through the formation of a thioester
 intermediate, analogous to the structurally unrelated HECT domain in
 eukaryotes.
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case <FTTag:act_site>
CC   -!- PTM: Ubiquitinated in the presence of host E1 ubiquitin-activating
CC       enzyme, E2 ubiquitin-conjugating enzyme and ubiquitin.
end case
CC   -!- SIMILARITY: Belongs to the LRR-containing bacterial E3 ligase
CC       family.
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GO   GO:0005576; C:extracellular region
case <FTTag:act_site>
GO   GO:0004842; F:ubiquitin-protein transferase activity
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KW   Ubl conjugation
KW   Transferase
end case
KW   Ubl conjugation pathway
KW   Host cytoplasm
KW   Secreted
FT   From: PS52053
FT   DOMAIN          from..to
FT                   /note="NEL #"
FT   ACT_SITE        89
FT                   /note="Glycyl thioester intermediate"
FT   Tag: act_site; Condition: C
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Chop: Nter=0; Cter=0;
Size: 280-295;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: A0A0H2USC0;
Scope:
 Bacteria; Pseudomonadota
Comments: None;
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# Revision 1.1 2024/10/22
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