AC   PRU01412;
DC   Domain;
TR   PROSITE; PS52066; MCM10_CTD; 1; level=0
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Names: MCM10 C-terminal domain (MCM10-CTD)
Function: The MCM10 CTD, although not present in unicellular eukaryotes, is
 conserved among metazoan species from nematodes to humans. The CTD contains a
 winged helix domain (WH) and two zinc chelating motifs, a CCCH zinc-finger
 (ZnF2) and a CCCC zinc-ribbon (ZnR). ssDNA binds only to ZnF2, whose
 structure is unique to MCM10. The ZnR is not involved in DNA binding.
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CC   -!- SIMILARITY: Belongs to the MCM10 family.
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GO   GO:0003697; F:single-stranded DNA binding
GO   GO:0006270; P:DNA replication initiation
GO   GO:0005634; C:nucleus
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
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KW   Metal-binding
KW   Zinc
KW   Zinc-finger
end case
KW   DNA replication
KW   Nucleus
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FT   From: PS52066
FT   DOMAIN          from..to
FT                   /note="MCM10-CTD #"
FT   REGION          from..64
FT                   /note="Winged helix (WH) #"
case <Feature:PS52066:74=[C]> and <Feature:PS52066:77=[C]> and <Feature:PS52066:88=[C]> and <Feature:PS52066:93=[H]>
FT   REGION          65..101
FT                   /note="CCCH-type zinc finger (ZnF2) #"
else case <FTGroup:1>
FT   REGION          65..101
FT                   /note="CCCH-type zinc finger (ZnF2) #; atypical"
else
FT   REGION          65..101
FT                   /note="CCCH-type zinc finger (ZnF2) #; degenerate"
end case
case <Feature:PS52066:107=[C]> and <Feature:PS52066:110=[C]> and <Feature:PS52066:125=[C]> and <Feature:PS52066:128=[C]>
FT   REGION          102..139
FT                   /note="CCCC-type zinc ribbon (ZnR) #"
else case <FTGroup:2>
FT   REGION          102..139
FT                   /note="CCCC-type zinc ribbon (ZnR) #; atypical"
else
FT   REGION          102..139
FT                   /note="CCCC-type zinc ribbon (ZnR) #; degenerate"
end case
FT   BINDING         74
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         77
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         88
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         93
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [CH]
FT   BINDING         107
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: [CH]
FT   BINDING         110
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: [CH]
FT   BINDING         125
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: [CH]
FT   BINDING         128
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: [CH]
XX
Chop: Nter=0; Cter=0;
Size: 146-162;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q5EAW4;
Scope:
 Eukaryota; Metazoa
Comments: None;
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# Version: 2
# Last updated date: 2025-06-05
# Created date: 2025-06-05
//