AC   PRU01417;
DC   Domain;
TR   PROSITE; PS52072; VPS10P; 1; level=0
XX
Names: Vacuolar protein sorting 10 protein (Vps10p) domain
Function: The Vps10p domain is formed by three structural units: a large N-
 terminal beta-propeller and two cysteine-knots called 10CCa and 10CCb, which
 constitute the so-called 10CC (ten conserved cysteines) module. The Vps10p
 propeller has a wide, open tunnel lined by ten edge strands running parallel
 to the propeller axis, thus providing ample opportunity for beta-sheet
 extension to capture extended peptides threaded into the tunnel. The C-
 terminal elongated 10CC module that partly wraps around the 'bottom' face of
 the propeller contains five conserved disulfide bridges and is a major
 ligand-binding region.
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KW   Receptor
KW   Transport
KW   Protein transport
case <FTTag:disulf>
KW   Disulfide bond
end case
XX
FT   From: PS52072
FT   DOMAIN          from..to
FT                   /note="Vps10p #"
FT   REGION          from..519
FT                   /note="10-bladed beta-propeller #"
FT   REGION          527..579
FT                   /note="10CCa cysteine-knot #"
FT   REGION          581..to
FT                   /note="10CCb cysteine-knot #"
FT   DISULFID        369..376
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        527..563
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        546..579
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        581..635
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        588..600
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        613..650
FT   Tag: disulf; Condition: C-x*-C
XX
XX
Chop: Nter=0; Cter=0;
Size: 133-728;
Related: None;
Repeats: 1-2;
Topology: Undefined;
Example: Q92673;
Scope:
 Eukaryota
Comments: None;
XX
# Version: 2
# Last updated date: 2025-07-09
# Created date: 2025-07-09
//