AC   PRU01419;
DC   Domain;
TR   PROSITE; PS52074; COV_4ECTO; 1; level=0
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Names: Coronavirus Nsp4 ectodomain (4Ecto)
Function: Nsp4 contains six transmembranes with its ectodomain (4Ecto)
 localized in the intermembrane space and its carboxy-terminal domain (CTD) in
 the DMV lumen, forming two layers of concentric stacking hexamers
 constituting the lower base of the pore complex. The 3Ecto domain attaches to
 the upper surface of the 4Ecto domain, which is mediated by a combination of
 hydrophobic and hydrophilic interactions.
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CC   -!- FUNCTION: [Non-structural protein 4]: Plays a role in the formation and
CC       maintenance of double membrane vesicles (DMVs) replication organelles.
CC       DMVs are formed by nsp3 and nsp4, while nsp6 zippers ER membranes and
CC       connects to lipid droplets.
CC   -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family.
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FT   From: PS52074
FT   DOMAIN          from..to
FT                   /note="4Ecto #"
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Chop: Nter=0; Cter=0;
Size: 235-252;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P0C6T5;
Scope:
 Viruses; Orthocoronavirinae
Comments: None;
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# Log: 
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