AC   PRU01421;
DC   Domain;
TR   PROSITE; PS52076; IFN_II; 1; level=0
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Names: Interferon (IFN) type-II family
Function: Tetrapods possess only a single copy of type II IFN gene, called
 IFN-gamma, which is mainly involved in immune regulation. In general, teleost
 fish are reported to have the composition of two type II IFN genes, including
 IFN-gamma and IFN-gamma-related (IFN-gammarel), except that two IFN-gamma
 genes were identified in channel catfish (named as IFN-gamma2a and IFN-
 gamma2b) and in ginbuna crucian carp (IFN-gamma1 and IFN-gamma2), and two
 IFN-gammarel genes were also reported in ginbuna crucian carp (IFN-gammarel1
 and IFN-gammarel2). Three members of type II IFN family, named as IFN-gamma-
 like, IFN-gamma and IFN-gammarel, were identified in the osteoglossiform
 fish, arapaima. IFN-gamma does possess some antiviral activity but is mainly
 an immunomodulatory cytokine acting on leukocytes.
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CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
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DR   PROSITE; PS00001; ASN_GLYCOSYLATION; 0-1; trigger=yes
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GO   GO:0005133; F:type II interferon receptor binding
GO   GO:0005125; F:cytokine activity
GO   GO:0005615; C:extracellular space
GO   GO:0002250; P:adaptive immune response
GO   GO:0006959; P:humoral immune response
GO   GO:0051607; P:defense response to virus
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KW   Cytokine
KW   Secreted
KW   Antiviral defense
KW   Growth regulation
case <FTTag:disulf>
KW   Disulfide bond
end case
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FT   From: PS52076
FT   DISULFID        40..42
FT   Tag: disulf; Condition: C-x*-C
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Chop: Nter=0; Cter=0;
Size: 128-175;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P79154;
Scope:
 Eukaryota; Euteleostomi
Comments: None;
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# Log: 
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