AC   PRU01434;
DC   Domain;
TR   PROSITE; PS50813; GAF; 1; level=0
XX
Names: GAF domain
Function: GAF domains in general may regulate allosterically catalytic
 activities via the binding of ligands, such as nucleotides and small
 molecules. Given the diverse evolutionary and functional contexts within
 which GAF domains are found, it has been proposed that not all these domains
 possess identical functions.
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case <Feature:PS50813:96-97=C-H> and <OC:Viridiplantae>
CC   -!- PTM: Contains one covalently linked phytochromobilin chromophore.
CC   -!- SIMILARITY: Belongs to the phytochrome family.
end case
case <Feature:PS50813:101-103=H-P>
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC       Note=Binds 1 heme group per monomer;
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KW   Heme
end case
XX
FT   From: PS50813
FT   DOMAIN          from..to
FT                   /note="GAF #"
case <Feature:PS50813:96-97=C-H> and <OC:Viridiplantae>
FT   BINDING         96
FT                   /ligand="phytochromobilin"
FT                   /ligand_id="ChEBI:CHEBI:189064"
FT                   /note="covalent"
else case <Feature:PS50813:96-97=C-H> and <OC:Cyanophyceae>
FT   BINDING         96
FT                   /ligand="(2R,3E)-phycocyanobilin"
FT                   /ligand_id="ChEBI:CHEBI:85275"
FT                   /note="covalent"
end case
case <Feature:PS50813:101-103=H-P-P>
FT   BINDING         101
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
end case
XX
Chop: Nter=0; Cter=0;
Size: 42-260;
Related: None;
Repeats: 1-3;
Topology: Undefined;
Example: P32039;
Scope:
 Bacteria
 Eukaryota
 Archaea; Stenosarchaea group
Comments: None;
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# Version: 2
# Last updated date: 2026-02-12
# Created date: 2026-02-06
//