AC   PRU01436;
DC   Domain;
TR   PROSITE; PS52090; H_NOX; 1; level=0
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Names: Heme-nitric oxide/oxygen binding (H-NOX) domain
Function: Heme-nitric oxide/oxygen binding (H-NOX) domains bind gaseous
 ligands for signal transduction in organisms spanning prokaryotic and
 eukaryotic kingdoms.
XX
case <Feature:PS52090:104=H>
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
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GO   GO:0020037; F:heme binding
end case
case <FTGroup:1>
GO   GO:0046872; F:metal ion binding
end case
XX
case <Feature:PS52090:104=H>
KW   Heme
end case
case <FTGroup:1>
KW   Zinc
KW   Metal-binding
end case
XX
FT   From: PS52090
FT   DOMAIN          from..to
FT                   /note="H-NOX #"
FT   BINDING         104
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   Condition: H
FT   BINDING         141
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         164
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [HQ]
FT   BINDING         167
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
FT   BINDING         178
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: C
XX
Chop: Nter=0; Cter=0;
Size: 109-211;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P20595;
Scope:
 Eukaryota; Metazoa
Comments: None;
XX
# Version: 2
# Last updated date: 2026-02-27
# Created date: 2026-02-25
//