AC   PRU01445;
DC   Domain;
TR   PROSITE; PS52101; PPK2; 1; level=0
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Names: Polyphosphate kinase family-2 (PPK2) domain
Function: In nature, polyphosphate (polyP) is synthesized and degraded by
 polyphosphate kinases (PPKs) that catalyze the reversible transfer of the
 terminal phosphoryl residue from nucleoside 5'-triphosphates to polyP. Two
 large, structurally unrelated families of bacterial PPKs have been
 characterized so far: PPK1 enzymes that favor polyP synthesis and the PPK2
 family that favors nucleotide phosphorylation.
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KW   Kinase
KW   Transferase
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FT   From: PS52101
FT   DOMAIN          from..to
FT                   /note="PPK2 #"
FT   MOTIF           51..57
FT                   /note="Walker A #"
FT   Condition: x(2)-[DE]-x(2)-G-K
FT   MOTIF           108..110
FT                   /note="Walker B #"
FT   Condition: [DN]-R-[ST]
FT   REGION          159..189
FT                   /note="lid module #"
FT   Condition: x(6)-R-x(12)-K-x(4)-D-x(6)
FT   ACT_SITE        53
FT   Condition: D
FT   BINDING         53
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="#2"
FT   Condition: [DE]
FT   BINDING         183
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="#1"
FT   Condition: D
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Chop: Nter=0; Cter=0;
Size: 113-253;
Related: None;
Repeats: 1-2;
Topology: Undefined;
Example: Q9HYF1;
Scope:
 Bacteria
Comments: None;
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# Version: 1
# Last updated date: 2026-04-22
# Created date: 2026-04-22
//