AC   PRU01451;
DC   Domain;
TR   PROSITE; PS52107; FV_VP40; 1; level=0
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Names: Filovirus VP40 matrix protein
Function: The filovirus matrix protein, VP40, binds to and concentrates at the
 plasma membrane of infected cells, where it can interact with components of
 the nucleocapsid to promote envelopment, and where it drives formation of the
 filamentous virus particles. In addition, VP40 has been shown to regulate
 viral replication and transcription.
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DE   AltName: Full=Matrix protein VP40;
DE   AltName: Full=Membrane-associated protein VP40;
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CC   -!- MISCELLANEOUS: Most abundant protein in the virion.
CC   -!- SIMILARITY: Belongs to the filoviridae matrix protein VP40 family.
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GO   GO:0039660; F:structural constituent of virion
GO   GO:0020002; C:host cell plasma membrane
GO   GO:0039702; P:viral budding via host ESCRT complex
GO   GO:0055036; C:virion membrane
GO   GO:0033645; C:host cell endomembrane system
GO   GO:0044185; C:host cell late endosome membrane
GO   GO:0052170; P:symbiont-mediated suppression of host innate immune response
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KW   Host cell membrane
KW   Host endosome
KW   Host membrane
KW   Host-virus interaction
KW   Inhibition of host innate immune response by virus
KW   Membrane
KW   Viral budding
KW   Viral budding via the host ESCRT complexes
KW   Viral immunoevasion
KW   Viral matrix protein
KW   Viral release from host cell
KW   Virion
case <FTTag:disulf>
KW   Disulfide bond
end case
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FT   From: PS52107
FT   DOMAIN          from..149
FT                   /note="Filovirus VP40 N-terminal #"
FT   DOMAIN          157..to
FT                   /note="Filovirus VP40 C-terminal #"
case <AnyFeature:PS52107:290-296=C-x*-C>
FT   DISULFID        290..296
FT   Tag: disulf
else case <AnyFeature:PS52107:287-290=C-x*-C>
FT   DISULFID        287..290
FT   Tag: disulf
end case
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Chop: Nter=0; Cter=0;
Size: 275-284;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P35260;
Scope:
 Viruses; Filoviridae
Comments: None;
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# Version: 1
# Last updated date: 2026-05-29
# Created date: 2026-05-29
//