AC   PRU10127;
DC   Protein;
TR   PROSITE; PS00171; TIM_1; 1; level=0
TR   PROSITE; PS51440; TIM_2; 1; level=0
XX
Names: Triosephosphate isomerase (TIM) family
Function: Triosephosphate isomerase (EC 5.3.1.1) (TIM) is the glycolytic
 enzyme that catalyzes the reversible interconversion of glyceraldehyde
 3-phosphate and dihydroxyacetone phosphate.
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case <FTGroup:1> and <FTGroup:2>
ID   TPIS
DE   + RecName: Full=Triosephosphate isomerase;
DE            Short=TIM;
DE            EC=5.3.1.1;
DE   AltName: Full=Triose-phosphate isomerase;
else case <FTGroup:1>
DE   + RecName: EC=5.3.1.-;
end case
case <FTGroup:1> and <FTGroup:2>
GN   Name=tpiA;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate;
CC         Xref=Rhea:RHEA:18585, ChEBI:CHEBI:57642, ChEBI:CHEBI:59776;
CC         EC=5.3.1.1;
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate from glycerone phosphate: step 1/1.
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
case <FTGroup:1> and <FTGroup:2> and <OC:Viridiplantae>
CC   -!- MISCELLANEOUS: In plants, there are two types of TPIS, cytosolic and
CC       plastid.
end case
CC   -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
XX
case <FTGroup:1> and <FTGroup:2>
GO   GO:0004807; F:triose-phosphate isomerase activity
GO   GO:0006096; P:glycolytic process
GO   GO:0006094; P:gluconeogenesis
GO   GO:0006098; P:pentose-phosphate shunt
GO   GO:0005737; C:cytoplasm
XX
KW   Isomerase
KW   Gluconeogenesis
KW   Glycolysis
KW   Pentose shunt
KW   Cytoplasm
end case
XX
FT   From: PS51440
FT   ACT_SITE        91
FT                   /note="Electrophile"
FT   Group: 1; Condition: H
FT   ACT_SITE        162
FT                   /note="Proton acceptor"
FT   Group: 1; Condition: E
case <FTGroup:1>
FT   BINDING         7
FT                   /ligand="substrate"
FT   Group: 2; Condition: N
FT   BINDING         9
FT                   /ligand="substrate"
FT   Group: 2; Condition: K
end case
FT   From: PS00171
case not <AnyFeature:PS51440>
FT   ACT_SITE        3
FT                   /note="Proton acceptor"
end case
XX
Chop: Nter=0; Cter=0;
Size: 200-290;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: Q928I1; P34937;
Scope:
 Eukaryota
 Bacteria
 Archaea
Comments: None
XX
# Revision 1.10 2022/05/14
//