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ProRule PRU00159


General rule information [?]

Accession PRU00159
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 47)
Data class Domain;
Predictors PROSITE; PS50011; PROTEIN_KINASE_DOM
Name Protein kinase domain
Function Undefined
Scope(s) Eukaryota
Bacteria
Viruses
Example(s) O54967 (ACK1_MOUSE);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <Feature:PS00108>
Protein name + AltName: EC=2.7.11.-;
else case <Feature:PS00109>
Protein name + AltName: EC=2.7.10.-;
else case <FT:4>
Protein name + AltName: EC=2.7.-.-;
end case
case <Feature:PS00108>
else case <Feature:PS00109> and <AnyFeature:PS51550>

Comments [?]

case <Feature:PS00108>
else case <Feature:PS00109>
case not <FTTag:active>
DOMAINThe protein kinase domain is predicted to be catalytically inactive.
end case
case <Feature:PS00108>
SIMILARITYBelongs to the protein kinase superfamily. Ser/Thr protein kinase family.
else case <Feature:PS00109> and <AnyFeature:PS51550>
SIMILARITYBelongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
else case <Feature:PS00109>
SIMILARITYBelongs to the protein kinase superfamily. Tyr protein kinase family.
end case

Keywords [?]

case <Feature:PS00108>
Kinase
Transferase
Serine/threonine-protein kinase
else case <Feature:PS00109>
Kinase
Transferase
Tyrosine-protein kinase
end case
case <FTTag:ATP>
ATP-binding
Nucleotide-binding
end case

Gene Ontology [?]

case <Feature:PS00108>
GO:0016301; Molecular function:kinase activity
GO:0016740; Molecular function:transferase activity
GO:0004674; Molecular function:protein serine/threonine kinase activity
else case <Feature:PS00109>
GO:0016301; Molecular function:kinase activity
GO:0016740; Molecular function:transferase activity
GO:0004713; Molecular function:protein tyrosine kinase activity
end case
case <FTTag:ATP>
GO:0005524; Molecular function:ATP binding
GO:0000166; Molecular function:nucleotide binding
end case

Cross-references [?]

PROSITE PS00107; PROTEIN_KINASE_ATP; 1;
PROSITE PS00107; PROTEIN_KINASE_ATP; 1;
PROSITE PS00108; PROTEIN_KINASE_ST; 1;
PROSITE PS00109; PROTEIN_KINASE_TYR; 1;

Features [?]

case <Feature:PS00108>
From: PS50011
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Protein kinase #"
case <Feature:PS50011:30=K> or <Feature:PS00107>
BINDING 7 15 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
ATP
end case
case <Feature:PS50011:30=K>
BINDING 30 30 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
end case
case <FTTag:ATP>
ACT_SITE 124 124 /note="Proton acceptor" active D
end case

Additional information [?]

Size range 205-549 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]