AC   PRU00297;
DC   Family;
TR   PROSITE; PS50873; PEROXIDASE_4; 1; level=0
XX
Names: Plant heme peroxidase
Function: Removal of H(2)O(2), oxidation of toxic reductants
XX
case <FTGroup:1> and <FTGroup:2> and <FTGroup:3> and <FTTag:viacarbo>
CC   -!- FUNCTION: Removal of H(2)O(2), oxidation of toxic reductants,
CC       biosynthesis and degradation of lignin, suberization, auxin catabolism,
CC       response to environmental stresses such as wounding, pathogen attack
CC       and oxidative stress. These functions might be dependent on each
CC       isozyme/isoform in each plant tissue.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AH2 + H2O2 = A + 2 H2O; Xref=Rhea:RHEA:30275,
CC         ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:17499;
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC       Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.;
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC       Note=Binds 2 calcium ions per subunit.;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the peroxidase family. Classical plant (class
CC       III) peroxidase subfamily.
end case
XX
case <FT:12>
DR   PROSITE; PS00435; PEROXIDASE_1; 1; trigger=no
end case
case <FT:11>
DR   PROSITE; PS00436; PEROXIDASE_2; 1; trigger=no
end case
XX
case <FTGroup:1> and <FTGroup:2> and <FTGroup:3> and <FTTag:viacarbo>
GO   GO:0016491; F:oxidoreductase activity
GO   GO:0004601; F:peroxidase activity
GO   GO:0009055; F:electron transfer activity
GO   GO:0006979; P:response to oxidative stress
GO   GO:0042744; P:hydrogen peroxide catabolic process
KW   Secreted
KW   Oxidoreductase
KW   Peroxidase
KW   Hydrogen peroxide
end case
case <FT:12>
GO   GO:0020037; F:heme binding
GO   GO:0005506; F:iron ion binding
KW   Iron
KW   Heme
end case
case <FT:17>
KW   Pyrrolidone carboxylic acid
end case
case <FTGroup:1> or <FTGroup:2>
GO   GO:0005509; F:calcium ion binding
KW   Calcium
end case
case <FT:12> or <FTGroup:1> or <FTGroup:2>
KW   Metal-binding
end case
case <FTTag:disulf>
KW   Disulfide bond
end case
FT   From: PS50873
FT   BINDING         43
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [DE]
FT   BINDING         46
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [VI]
FT   BINDING         48
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: G
FT   BINDING         50
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [DE]
FT   BINDING         52
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#1"
FT   Group: 1; Condition: [ST]
FT   BINDING         169
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: [TS]
FT   BINDING         222
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: [DE]
FT   BINDING         225
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: [TS]
FT   BINDING         230
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="#2"
FT   Group: 2; Condition: [DE]
FT   SITE            38
FT                   /note="Transition state stabilizer"
FT   Group: 3; Condition: R
FT   ACT_SITE        42
FT                   /note="Proton acceptor"
FT   Group: 3; Condition: H
FT   BINDING         168
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Group: 3; Condition: H
FT   DISULFID        11..90
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        44..49
FT   Tag: disulf, viacarbo; Condition: C-x*-C
FT   DISULFID        96..298
FT   Tag: disulf; Condition: C-x*-C
FT   DISULFID        175..207
FT   Tag: disulf; Condition: C-x*-C
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT   Condition: Q
case <FTTag:viacarbo>
FT   BINDING         138
FT                   /ligand="substrate"
FT   Condition: P
end case
XX
Chop: Nter=0; Cter=0;
Size: 250-384;
Related: None;
Repeats: 1;
Topology: Undefined;
Example: P0DI10; Q67Z07;
Scope:
 Eukaryota
Comments: None
XX
# Revision 1.37 2022/11/19
//