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ProRule PRU00312


General rule information [?]

Accession PRU00312
Dates 12-JAN-2004 (Created)
27-JUN-2022 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS50953; KID
Name KID domain
Function Ser-133 phosphorylation of CREB within the KID domain promotes target gene activation via complex formation with the KIX domain of the CBP and P300 coactivators, whereas concurrent phosphorylation of the CREB KID domain at Ser-142 inhibits transcriptional induction.
Scope(s) Eukaryota
Metazoa
Example(s) P16220 (CREB1_HUMAN);

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

DNA-binding
Nucleus
case <Feature:PS50953:33=S> or <Feature:PS50953:42=S>
Phosphoprotein
end case
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0005634; Cellular component:nucleus
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Features [?]

From: PS50953
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="KID #"
MOD_RES 33 33 /note="Phosphoserine" S
MOD_RES 42 42 /note="Phosphoserine" S

Additional information [?]

Size range 55-65 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]