annotation rule: PRU00408

General rule information [?]

Accession PRU00408
Dates 3-MAR-2005 (Created)
16-DEC-2016 (Last updated, Version 13)
Data class Domain
Predictors PROSITE; PS50879; RNASE_H
Name Ribonuclease H domain
Function Ribonuclease H (RNase H) (EC recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes.

Propagated annotation [?]

Description [?]

+ RecName: EC=;

Comments [?]

Catalytic activity Endonucleolytic cleavage to 5'-phosphomonoester.

Gene Ontology [?]

GO:0004519; Molecular function: endonuclease activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0004518; Molecular function: nuclease activity.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case

Keywords [?]

case <FTGroup:1>
end case

Features [?]

From: PS50879
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       RNase H        
case not <OC:Bacteria> and not <OC:Archaea>
METAL     10     10       Magnesium     D   1
METAL     50     50       Magnesium     E   1
METAL     74     74       Magnesium     D   1
METAL     127     127       Magnesium     D   1
end case

Additional information [?]

Size range 101-205 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q08885 (RNH_BUCAP)
Scope Eukaryota


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to or see: prosite_license.html.

UniProtKB rule member sequences [?]