annotation rule: PRU00859

General rule information [?]

Accession PRU00859
Dates 9-JUN-2011 (Created)
7-MAR-2017 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51527; FLAVIVIRUS_NS2B
Name Flavivirus NS2B domain
Function The NS3pro has a classical serine protease catalytic triad (His, Asp, and Ser). The enzymatic activity of NS3pro is enhanced by interacting with the central 40 amino acid of NS2B which acts as an essential cofactor.

Propagated annotation [?]


Comments [?]

Function Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.

Gene Ontology [?]

GO:0033644; Cellular component: host cell membrane.
GO:0016020; Cellular component: membrane.
GO:0044165; Cellular component: host cell endoplasmic reticulum.
GO:0016021; Cellular component: integral component of membrane.

Keywords [?]


Features [?]

From: PS51527
Key     From     To       Description   Tag   Condition   FTGroup
REGION     54     93       Interacts with and activates NS3 protease        

Additional information [?]

Size range 120-143 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P07564 (POLG_DEN2J)
Scope Viruses; Flavivirus
Comments None

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]