AC PRU01030; DC Domain; TR PROSITE; PS51693; HCV_NS2_PRO; 1; level=0 XX Names: Hepacivirus nonstructural protein 2 (NS2) protease domain Function: NS2 is a 217 amino acids (aa) long cysteine-protease composed of a highly hydrophobic N-terminal membrane binding domain (MBD) and a C-terminal globular and cytosolic protease domain. The HCV NS2 protease domain forms the peptidase family C18. XX case DE + Contains: DE RecName: Full=Protease NS2-3; DE Short=p23; DE EC=3.4.22.-; end case XX XX case GO GO:0004197; F:cysteine-type endopeptidase activity XX KW Hydrolase KW Protease KW Thiol protease end case XX FT From: PS51693 FT DOMAIN from..to FT /note="Peptidase C18 #" FT ACT_SITE 50 FT /note="For protease NS2-3 activity; shared with dimeric FT partner" FT Group: 1; Condition: H FT ACT_SITE 70 FT /note="For protease NS2-3 activity; shared with dimeric FT partner" FT Group: 1; Condition: E FT ACT_SITE 91 FT /note="For protease NS2-3 activity; shared with dimeric FT partner" FT Group: 1; Condition: C case FT CHAIN ?..124 FT /note="Protease NS2-3" FT SITE 124..124+1 FT /note="Cleavage; by protease NS2-3" end case XX Chop: Nter=0; Cter=0; Size: 112-138; Related: None; Repeats: 1; Topology: Undefined; Example: Q9WMX2; Scope: Viruses; Flaviviridae Comments: None; XX # Revision 1.6 2019/11/22 //