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ProRule PRU01336


General rule information [?]

Accession PRU01336
Dates 7-JAN-2022 (Created)
6-APR-2023 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51992; COV_NSP3_Y
Name Coronavirus (CoV) Nsp3 Y domain
Function The Y domains including Y1 and CoV-Y may form higher-order oligomeric complexes and play a role in pore formation in double-membrane vesicles (DMVs) that serve as the central hubs for viral RNA replication. Specific membrane binding might be a conserved activity of the Y domain.
Scope(s) Viruses
Orthocoronavirinae
Example(s) P0DTD1 (R1AB_SARS2);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the coronaviruses polyprotein 1ab family.

Keywords [?]


Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51992
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CoV Nsp3 Y #"
REGION 92 to /note="CoV-Y #"
REGION from 91 /note="Y1 #"
REGION 92 186 /note="Y2 #"
REGION 187 268 /note="Y3 #"
REGION 269 to /note="Y4 #"
REGION 5 18 /note="ZF1 #" 1
BINDING 5 5 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
H 1
BINDING 10 10 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
C 1
BINDING 15 15 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
C 1
BINDING 18 18 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
C 1
REGION 51 61 /note="ZF2 #" 2
BINDING 51 51 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
C 2
BINDING 54 54 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
H 2
BINDING 58 58 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
C 2
BINDING 61 61 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
C 2

Additional information [?]

Size range 340-374 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]