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PROSITE documentation PDOC00005

Protein kinase C phosphorylation site


In vivo, protein kinase C exhibits a preference for the phosphorylation of serine or threonine residues found close to a C-terminal basic residue [1,2]. The presence of additional basic residues at the N- or C-terminal of the target amino acid enhances the Vmax and Km of the phosphorylation reaction.

Last update:

June 1988 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

PKC_PHOSPHO_SITE, PS00005; Protein kinase C phosphorylation site  (PATTERN with a high probability of occurrence!)


1AuthorsWoodget J.R. Gould K.L. Hunter T.
SourceEur. J. Biochem. 161:177-184(1986).

2AuthorsKishimoto A. Nishiyama K. Nakanishi H. Uratsuji Y. Nomura H. Takeyama Y. Nishizuka Y.
TitleStudies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase.
SourceJ. Biol. Chem. 260:12492-12499(1985).
PubMed ID2413024

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