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Database of protein domains, families and functional sites

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Our latest paper, which we dedicate to Amos Bairoch (1957–2025), has been published.

PROSITE consists of documentation entries describing protein domains, families and functional sites as well as associated patterns and profiles to identify them [More... / References / Commercial users ].
PROSITE is complemented by ProRule , a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids [More...].


Release 2026_01 of 28-Jan-2026 contains 1967 documentation entries, 1311 patterns, 1419 profiles and 1441 ProRule.
Search PROSITE
e.g. PDOC00022, PS50089, SH3, zinc finger
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Browse PROSITE
Quick Scan mode of ScanProsite
Quickly find matches of your protein sequences to PROSITE signatures (max. 10 sequences). [?] Examples

For UniProtKB/TrEMBL accessions/identifiers, only those of entries belonging to reference proteomes are accepted.

Exclude motifs with a high probability of occurrence from the scan

For more scanning options go to ScanProsite
Other tools
PRATT
allows to interactively generate conserved patterns from a series of unaligned proteins.
MyDomains - Image Creator
allows to generate custom domain figures.
scanview