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Database of protein domains, families and functional sites

new icon SARS-CoV-2 relevant PROSITE motifs

PROSITE consists of documentation entries describing protein domains, families and functional sites as well as associated patterns and profiles to identify them [More... / References / Commercial users ].
PROSITE is complemented by ProRule , a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids [More...].

Release 2022_04 of 12-Oct-2022 contains 1914 documentation entries, 1311 patterns, 1350 profiles and 1363 ProRule.

e.g. PDOC00022, PS50089, SH3, zinc finger

Quick Scan mode of ScanProsite
Quickly find matches of your protein sequences to PROSITE signatures (max. 10 sequences). [?] Examples

For UniProtKB/TrEMBL accessions/identifiers, only those of entries belonging to reference proteomes are accepted.

Exclude motifs with a high probability of occurrence from the scan

For more scanning options go to ScanProsite
Other tools
  • PRATT -  allows to interactively generate conserved patterns from a series of unaligned proteins.
  • MyDomains - Image Creator -  allows to generate custom domain figures.