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Database of protein domains, families and functional sites

new icon SARS-CoV-2 relevant PROSITE motifs

PROSITE consists of documentation entries describing protein domains, families and functional sites as well as associated patterns and profiles to identify them [More... / References / Commercial users ].
PROSITE is complemented by ProRule , a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids [More...].

Release 2022_04 of 12-Oct-2022 contains 1914 documentation entries, 1311 patterns, 1350 profiles and 1363 ProRule.

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e.g. PDOC00022, PS50089, SH3, zinc finger





Quick Scan mode of ScanProsite
Quickly find matches of your protein sequences to PROSITE signatures (max. 10 sequences). [?] Examples

For UniProtKB/TrEMBL accessions/identifiers, only those of entries belonging to reference proteomes are accepted.

Exclude motifs with a high probability of occurrence from the scan

For more scanning options go to ScanProsite
Other tools
  • PRATT -  allows to interactively generate conserved patterns from a series of unaligned proteins.
  • MyDomains - Image Creator -  allows to generate custom domain figures.
scanview