Database of protein domains, families and functional sites

PROSITE consists of documentation entries describing protein domains, families and functional sites as well as associated patterns and profiles to identify them [More... / References / Commercial users].
PROSITE is complemented by ProRule, a collection of rules based on profiles and patterns, which increases the discriminatory power of profiles and patterns by providing additional information about functionally and/or structurally critical amino acids [More...].

Release 2018_02 of 28-Feb-2018 contains 1803 documentation entries, 1309 patterns, 1210 profiles and 1231 ProRule.

e.g. PDOC00022, PS50089, SH3, zinc finger


Quick Scan mode of ScanProsite
Quickly find matches of your protein sequences to PROSITE signatures (max. 10 sequences). [?] Examples

Exclude motifs with a high probability of occurrence from the scan

For more scanning options go to ScanProsite
Other tools
  • PRATT -  allows to interactively generate conserved patterns from a series of unaligned proteins.
  • MyDomains - Image Creator -  allows to generate custom domain figures.