Substrates of tyrosine protein kinases are generally characterized by a lysine
or an arginine seven residues to the N-terminal side of the phosphorylated
tyrosine. An acidic residue (Asp or Glu) is often found at either three or
four residues to the N-terminal side of the tyrosine [1,2,3]. There are a
number of exceptions to this rule such as the tyrosine phosphorylation sites
of enolase and lipocortin II.
June 1988 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Patschinsky T. Hunter T. Esch F.S. Cooper J.A. Sefton B.M.
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.
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