PROSITE documentation PDOC00016
Cell attachment sequence


The sequence Arg-Gly-Asp, found in fibronectin, is crucial for its interaction with its cell surface receptor, an integrin [1,2]. What has been called the 'RGD' tripeptide is also found in the sequences of a number of other proteins, where it has been shown to play a role in cell adhesion. These proteins are: some forms of collagens, fibrinogen, vitronectin, von Willebrand factor (VWF), snake disintegrins, and slime mold discoidins. The 'RGD' tripeptide is also found in other proteins where it may also, but not always, serve the same purpose.

Last update:

December 1991 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RGD, PS00016; Cell attachment sequence  (PATTERN with a high probability of occurrence!)


1AuthorsRuoslahti E. Pierschbacher M.D.
TitleArg-Gly-Asp: a versatile cell recognition signal.
SourceCell 44:517-518(1986).
PubMed ID2418980

2Authorsd'Souza S.E. Ginsberg M.H. Plow E.F.
SourceTrends Biochem. Sci. 16:246-250(1991).

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