We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00102Phosphoglycerate kinase signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00102
Description
Phosphoglycerate kinase (EC 2.7.2.3) (PGK) [1] catalyzes the second step in the second phase of glycolysis, the reversible conversion of 1,3-diphospho-glycerate to 3-phosphoglycerate with generation of one molecule of ATP. PGK is found in all living organisms and its sequence has been highly conserved throughout evolution. It is a two-domain protein; each domain is composed of six repeats of an α/β structural motif. As a signature pattern for PGK's, we selected a conserved region in the N-terminal region.
Last update:July 1999 / Pattern and text revised.
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Technical section
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Reference
| 1 | Authors | Watson H.C. Littlechild J.A. |
| Title | Isoenzymes of phosphoglycerate kinase: evolutionary conservation of the structure of this glycolytic enzyme. | |
| Source | Biochem. Soc. Trans. 18:187-190(1990). | |
| PubMed ID | 2379683 |
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