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PROSITE documentation PDOC00102Phosphoglycerate kinase signature
Description
Phosphoglycerate kinase (EC 2.7.2.3) (PGK) [1] catalyzes the second step in the second phase of glycolysis, the reversible conversion of 1,3-diphospho-glycerate to 3-phosphoglycerate with generation of one molecule of ATP. PGK is found in all living organisms and its sequence has been highly conserved throughout evolution. It is a two-domain protein; each domain is composed of six repeats of an α/β structural motif. As a signature pattern for PGK's, we selected a conserved region in the N-terminal region.
Last update:July 1999 / Pattern and text revised.
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Technical section
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Reference
| 1 | Authors | Watson H.C. Littlechild J.A. |
| Title | Isoenzymes of phosphoglycerate kinase: evolutionary conservation of the structure of this glycolytic enzyme. | |
| Source | Biochem. Soc. Trans. 18:187-190(1990). | |
| PubMed ID | 2379683 |
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