PROSITE documentation PDOC00102
Phosphoglycerate kinase signature


Phosphoglycerate kinase (EC (PGK) [1] catalyzes the second step in the second phase of glycolysis, the reversible conversion of 1,3-diphospho-glycerate to 3-phosphoglycerate with generation of one molecule of ATP. PGK is found in all living organisms and its sequence has been highly conserved throughout evolution. It is a two-domain protein; each domain is composed of six repeats of an α/β structural motif. As a signature pattern for PGK's, we selected a conserved region in the N-terminal region.

Last update:

July 1999 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PGLYCERATE_KINASE, PS00111; Phosphoglycerate kinase signature  (PATTERN)


1AuthorsWatson H.C. Littlechild J.A.
TitleIsoenzymes of phosphoglycerate kinase: evolutionary conservation of the structure of this glycolytic enzyme.
SourceBiochem. Soc. Trans. 18:187-190(1990).
PubMed ID2379683

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