Home  |  Contact
PROSITE documentation PDOC00138

ATP synthase gamma subunit signature





Description

ATP synthase (proton-translocating ATPase) (EC 3.6.3.14) [1,2] is a component of the cytoplasmic membrane of eubacteria, the inner membrane of mitochondria, and the thylakoid membrane of chloroplasts. The ATPase complex is composed of an oligomeric transmembrane sector, called CF(0), and a catalytic core, called coupling factor CF(1). The former acts as a proton channel; the latter is composed of five subunits, α, β, γ, delta and epsilon. Subunit γ is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. The best conserved region of the γ subunit [3] is its C-terminus which seems to be essential for assembly and catalysis. As a signature pattern to detect ATPase γ subunits, we used a 14 residue conserved segment where the last amino acid is found one to three residues from the C-terminal extremity.

Last update:

November 1995 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

ATPASE_GAMMA, PS00153; ATP synthase gamma subunit signature  (PATTERN)


References

1AuthorsFutai M. Noumi T. Maeda M.
TitleATP synthase (H+-ATPase): results by combined biochemical and molecular biological approaches.
SourceAnnu. Rev. Biochem. 58:111-136(1989).
PubMed ID2528322
DOI10.1146/annurev.bi.58.070189.000551

2AuthorsSenior A.E.
TitleATP synthesis by oxidative phosphorylation.
SourcePhysiol. Rev. 68:177-231(1988).
PubMed ID2892214

3AuthorsMiki J. Maeda M. Mukohata Y. Futai M.
TitleThe gamma-subunit of ATP synthase from spinach chloroplasts. Primary structure deduced from the cloned cDNA sequence.
SourceFEBS Lett. 232:221-226(1988).
PubMed ID2896606



PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)