We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00139P-type ATPases phosphorylation site
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00139
Description
P-type ATPases (also known as E1-E2) are cation transport ATPases which form an aspartyl phosphate intermediate in the course of ATP hydrolysis. ATPases which belong to this family are listed below [1,2,3].
- Fungal and plant plasma membrane (H+) ATPases (EC 3.6.3.6).
- Vertebrate (Na+, K+) ATPases (sodium pump) (EC 3.6.3.9).
- Gastric (K+, H+) ATPases (proton pump) (EC 3.6.3.10).
- Calcium (Ca++) ATPases (calcium pump) (EC 3.6.3.8) from the sarcoplasmic reticulum (SR), the endoplasmic reticulum (ER) and the plasma membrane.
- Copper (Cu++) ATPases (copper pump) (EC 3.6.3.4) which are involved in two human genetic disorders: Menkes syndrome and Wilson disease.
- Bacterial cadmium efflux (Cd++) ATPases (EC 3.6.3.3).
- Bacterial magnesium (Mg++) ATPases (EC 3.6.3.2).
- Bacterial potassium (K+) ATPases (EC 3.6.3.12).
- Bacterial zinc (Zn+) ATPases (EC 3.6.3.5).
- Fungal ENA sodium ATPases (EC 3.6.3.7).
- fixI, a probable cation ATPase from Rhizobacea, involved in nitrogen fixation.
The region around the phosphorylated aspartate residue is perfectly conserved in all these ATPases and can be used as a signature pattern.
Last update:November 2002 / Text revised.
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Technical section
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References
| 1 | Authors | Fagan M.J. Saier M.H. Jr. |
| Title | P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees. | |
| Source | J. Mol. Evol. 38:57-99(1994). | |
| PubMed ID | 8151716 |
| 2 | Authors | Palmgren M.G. Axelsen K.B. |
| Title | Evolution of P-type ATPases. | |
| Source | Biochim. Biophys. Acta 1365:37-45(1998). | |
| PubMed ID | 9693719 |
| 3 | Authors | Axelsen K.B. Palmgren M.G. |
| Title | Evolution of substrate specificities in the P-type ATPase superfamily. | |
| Source | J. Mol. Evol. 46:84-101(1998). | |
| PubMed ID | 9419228 |
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