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PROSITE documentation PDOC00189
Solute carrier (Solcar) repeat profile

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PURL: https://purl.expasy.org/prosite/documentation/PDOC00189

Description

Different types of substrate carrier proteins involved in energy transfer are found in the inner mitochondrial membrane [1,2,3,4,5]. These are:

The ADP,ATP carrier protein (AAC) (ADP/ATP translocase) which exports ATP into the cytosol and imports ADP into the mitochondrial matrix. The sequence of AAC has been obtained from various mammalian, plant and fungal species.
The 2-oxoglutarate/malate carrier protein (OGCP), which exports 2-oxoglutarate into the cytosol and imports malate or other dicarboxylic acids into the mitochondrial matrix. This protein plays an important role in several metabolic processes such as the malate/aspartate and the oxoglutarate/isocitrate shuttles.
The phosphate carrier protein, which transports phosphate groups from the cytosol into the mitochondrial matrix.
The brown fat uncoupling protein (UCP) which dissipates oxidative energy into heat by transporting protons from the cytosol into the mitochondrial matrix.
The tricarboxylate transport protein (or citrate transport protein) which is involved in citrate-H+/malate exchange. It is important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD for the glycolytic pathway.
The Grave's disease carrier protein (GDC), a protein of unknown function recognized by IgG in patients with active Grave's disease.
Yeast mitochondrial proteins MRS3 and MRS4. The exact function of these proteins is not known. They suppress a mitochondrial splice defect in the first intron of the COB gene and may act as carriers, exerting their suppressor activity by modulating solute concentrations in the mitochondrion.
Yeast mitochondrial FAD carrier protein (gene FLX1).
Yeast protein ACR1 [6], which seems essential for acetyl-CoA synthase activity.
Yeast protein PET8.
Yeast protein PMT.
Yeast protein RIM2.
Yeast protein YHM1/SHM1.
Yeast protein YMC1.
Yeast protein YMC2.
Yeast hypothetical proteins YBR291c, YEL006w, YER053c, YFR045w, YHR002w, and YIL006w.
Caenorhabditis elegans hypothetical protein K11H3.3.

Two other proteins have been found to belong to this family, yet are not localized in the mitochondrial inner membrane:

Maize amyloplast Brittle-1 protein. This protein, found in the endosperm of kernels, could play a role in amyloplast membrane transport.
Candida boidinii peroxisomal membrane protein PMP47 [7]. PMP47 is an integral membrane protein of the peroxisome and it may play a role as a transporter.

These proteins all seem to be evolutionary related. Structurally, they consist of three tandem repeats of a domain of approximately one hundred residues. Each of these domains contains two transmembrane regions.

The profile we developed covers the entire solute carrier (Solcar) repeat.

Last update:

August 2003 / Pattern removed and profile added.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

SOLCAR, PS50920; Solute carrier (Solcar) repeat profile (MATRIX)

Sequences in UniProtKB/Swiss-Prot known to belong to this class: 498
- detected by PS50920: 497 (true positives)
- undetected by PS50920: 1 (1 false negative and 0 'partial')
Other sequence(s) in UniProtKB/Swiss-Prot detected by PS50920:
NONE.
Domain architecture view of Swiss-Prot proteins matching PS50920
Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
Clustal format, color, condensed view / Clustal format, color / Clustal format, plain text / Fasta format
Retrieve the sequence logo from the alignment
Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS50920
Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS50920
Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS50920
Matching PDB structures: pdb_00001okc pdb_00002c3e pdb_00002lck pdb_00004c9g ... [ALL]

References

1	Authors	Klingenberg M.
	Title	Mechanism and evolution of the uncoupling protein of brown adipose tissue.
	Source	Trends Biochem. Sci. 15:108-112(1990).
	PubMed ID	2158156

2	Authors	Walker J.E.
2	Source	Curr. Opin. Struct. Biol. 2:519-526(1992).

3	Authors	Kuan J. Saier M.H. Jr.
3	Source	CRC Crit. Rev. Biochem. 28:209-233(1993).

4	Authors	Kuan J. Saier M.H. Jr.
	Title	Expansion of the mitochondrial carrier family.
	Source	Res. Microbiol. 144:671-672(1993).
	PubMed ID	8140286

5	Authors	Nelson D.R. Lawson J.E. Klingenberg M. Douglas M.G.
	Title	Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential.
	Source	J. Mol. Biol. 230:1159-1170(1993).
	PubMed ID	8487299

6	Authors	Palmieri F.
	Title	Mitochondrial carrier proteins.
	Source	FEBS Lett. 346:48-54(1994).
	PubMed ID	8206158

7	Authors	Jank B. Habermann B. Schweyen R.J. Link T.A.
	Title	PMP47, a peroxisomal homologue of mitochondrial solute carrier proteins.
	Source	Trends Biochem. Sci. 18:427-428(1993).
	PubMed ID	8291088

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PROSITE documentation PDOC00189Solute carrier (Solcar) repeat profile

PROSITE documentation PDOC00189
Solute carrier (Solcar) repeat profile