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PROSITE documentation PDOC00200

Tubulin-beta mRNA autoregulation signal





Description

The stability of β-tubulin mRNAs are autoregulated by their own translation product [1]. Unpolymerized tubulin subunits bind directly (or activate a factor(s) which binds co-translationally) to the nascent N-terminus of β-tubulin. This binding is transduced through the adjacent ribosomes to activate an RNAse that degrades the polysome-bound mRNA. The recognition element has been shown to be the first four amino acids of β-tubulin: Met-Arg-Glu-Ile. Mutations to this sequence abolish the autoregulation effect (except for the replacement of Glu by Asp); transposition of this sequence to an internal region of a polypeptide also suppresses the autoregulatory effect.

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Last update:

May 1991 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

?, PS00228;   (?)


Reference



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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