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PROSITE documentation PDOC00200

Tubulin-beta mRNA autoregulation signal





Description

The stability of β-tubulin mRNAs are autoregulated by their own translation product [1]. Unpolymerized tubulin subunits bind directly (or activate a factor(s) which binds co-translationally) to the nascent N-terminus of β-tubulin. This binding is transduced through the adjacent ribosomes to activate an RNAse that degrades the polysome-bound mRNA. The recognition element has been shown to be the first four amino acids of β-tubulin: Met-Arg-Glu-Ile. Mutations to this sequence abolish the autoregulation effect (except for the replacement of Glu by Asp); transposition of this sequence to an internal region of a polypeptide also suppresses the autoregulatory effect.

Last update:

May 1991 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

TUBULIN_B_AUTOREG, PS00228; Tubulin-beta mRNA autoregulation signal  (PATTERN)


Reference

1AuthorsCleveland D.W.
TitleAutoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism.
SourceTrends Biochem. Sci. 13:339-343(1988).
PubMed ID3072712



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