PROSITE documentation PDOC00200Tubulin-beta mRNA autoregulation signal
The stability of β-tubulin mRNAs are autoregulated by their own translation product [1]. Unpolymerized tubulin subunits bind directly (or activate a factor(s) which binds co-translationally) to the nascent N-terminus of β-tubulin. This binding is transduced through the adjacent ribosomes to activate an RNAse that degrades the polysome-bound mRNA. The recognition element has been shown to be the first four amino acids of β-tubulin: Met-Arg-Glu-Ile. Mutations to this sequence abolish the autoregulation effect (except for the replacement of Glu by Asp); transposition of this sequence to an internal region of a polypeptide also suppresses the autoregulatory effect.
Last update:May 1991 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Cleveland D.W. |
| Title | Autoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism. | |
| Source | Trends Biochem. Sci. 13:339-343(1988). | |
| PubMed ID | 3072712 |
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