We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00202Neuraxin and MAP1B proteins repeated region signature
View entry in original PROSITE document format
View entry in raw text format (no links)
PURL: https://purl.expasy.org/prosite/documentation/PDOC00202
Description
MAP1B [1], and neuraxin [2] are neuronal microtubule-binding proteins. Both proteins contain a region that consists of 12 tandem repeats of a 17 residues motif.
The pattern we developed to detect this repeated region corresponds to the N-terminal ten residues of the repeated region.
Expert(s) to contact by email: Last update:December 2004 / Pattern and text revised.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Noble M. Lewis S.A. Cowan N.J. |
| Title | The microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau. | |
| Source | J. Cell Biol. 109:3367-3376(1989). | |
| PubMed ID | 2480963 |
| 2 | Authors | Rienitz A. Grenningloh G. Hermans-Borgmeyer I. Kirsch J. Littauer U.Z. Prior P. Gundelfinger E.D. Schmitt B. Betz H. |
| Title | Neuraxin, a novel putative structural protein of the rat central nervous system that is immunologically related to microtubule- associated protein 5. | |
| Source | EMBO J. 8:2879-2888(1989). | |
| PubMed ID | 2555150 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.