PROSITE documentation PDOC00213Receptor tyrosine kinase class III signature
A number of growth factors stimulate mitogenesis by interacting with a family of cell surface receptors which possess an intrinsic, ligand-sensitive, protein tyrosine kinase activity [1]. These receptor tyrosine kinases (RTK) all share the same topology: an extracellular ligand-binding domain, a single transmembrane region and a cytoplasmic kinase domain. However they can be classified into at least five groups. The class III RTK's are characterized by the presence of five to seven immunoglobulin-like domains [2] in their extracellular section. Their kinase domain differs from that of other RTK's by the insertion of a stretch of 70 to 100 hydrophilic residues in the middle of this domain. The receptors currently known to belong to class III are:
- Platelet-derived growth factor receptor (PDGF-R). PDGF-R exists as a homo- or heterodimer of two related chains: α and β [3].
- Macrophage colony stimulating factor receptor (CSF-1-R) (also known as the fms oncogene).
- Stem cell factor (mast cell growth factor) receptor (also known as the kit oncogene).
- Vascular endothelial growth factor (VEGF) receptors Flt-1 and Flk-1/KDR [4].
- Fl cytokine receptor Flk-2/Flt-3 [5].
- The putative receptor Flt-4 [6].
We developed a signature pattern for this class of RTK's which is based on a conserved region in the kinase domain.
Last update:December 2001 / Text revised.
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PROSITE method (with tools and information) covered by this documentation:
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| Title | Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. | |
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| Title | The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor. | |
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| PubMed ID | 8386825 |
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