PROSITE documentation PDOC00228Interleukin-7 and -9 signature
Description
Interleukin-7 (IL-7) [1] is a cytokine that serves as a growth factor for early lymphoid cells of both B- and T-cell lineages. Interleukin-9 (IL-9) [2] is a cytokine that supports IL-2 independent and IL-4 independent growth of helper T-cells.
Interleukin-7 and -9 seems to be evolutionary related [3]. As a signature pattern, we selected a conserved region located in the C-terminal section of the protein.
Expert(s) to contact by email: Last update:July 1998 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Henney C.S. |
| Title | Interleukin 7: effects on early events in lymphopoiesis. | |
| Source | Immunol. Today. 10:170-173(1989). | |
| PubMed ID | 2663018 |
| 2 | Authors | Renauld J.C. Goethals A. Houssiau F. Merz H. Van Roost E. Van Snick J. |
| Title | Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene. | |
| Source | J. Immunol. 144:4235-4241(1990). | |
| PubMed ID | 1971295 |
| 3 | Authors | Boulay J.-L. Paul W.E. |
| Title | Hematopoietin sub-family classification based on size, gene organization and sequence homology. | |
| Source | Curr. Biol. 3:573-581(1993). | |
| PubMed ID | 15335670 |
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