We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00228Interleukin-7 and -9 signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00228
Description
Interleukin-7 (IL-7) [1] is a cytokine that serves as a growth factor for early lymphoid cells of both B- and T-cell lineages. Interleukin-9 (IL-9) [2] is a cytokine that supports IL-2 independent and IL-4 independent growth of helper T-cells.
Interleukin-7 and -9 seems to be evolutionary related [3]. As a signature pattern, we selected a conserved region located in the C-terminal section of the protein.
Expert(s) to contact by email: Last update:July 1998 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Henney C.S. |
| Title | Interleukin 7: effects on early events in lymphopoiesis. | |
| Source | Immunol. Today. 10:170-173(1989). | |
| PubMed ID | 2663018 |
| 2 | Authors | Renauld J.C. Goethals A. Houssiau F. Merz H. Van Roost E. Van Snick J. |
| Title | Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene. | |
| Source | J. Immunol. 144:4235-4241(1990). | |
| PubMed ID | 1971295 |
| 3 | Authors | Boulay J.-L. Paul W.E. |
| Title | Hematopoietin sub-family classification based on size, gene organization and sequence homology. | |
| Source | Curr. Biol. 3:573-581(1993). | |
| PubMed ID | 15335670 |
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