PROSITE documentation PDOC00236
Natriuretic peptides signature


Atrial natriuretic peptides (ANP) [1,2,3] are vertebrate hormones important in the overall control of cardiovascular homeostasis and sodium and water balance in general. There are various ANP peptides which vary in length but which have a common central core; they are all processed from a single precursor. There is a disulfide bond which is important for the expression of the biological activity.

The ANP protein family includes three additional structurally related peptides which elicit a pharmacological spectrum similar to ANP:

  • Brain natriuretic peptide (BNP).
  • C-type natriuretic peptide (CNP).
  • Ventricular natriuretic peptide (VNP) [4].
  • Green mamba natriuretic peptide (DNP) [5].

The signature developed for the ANP family includes the two cysteines involved in the disulfide bond and two conserved glycines which may be important for the conformation of the peptides.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

NATRIURETIC_PEPTIDE, PS00263; Natriuretic peptides signature  (PATTERN)


1AuthorsInagami T.
TitleAtrial natriuretic factor.
SourceJ. Biol. Chem. 264:3043-3046(1989).
PubMed ID2536732

2AuthorsSagnella G.A. McGregor G.A.
SourceTrends Biochem. Sci. 11:299-302(1986).

3AuthorsRosenzweig A. Seidman C.E.
TitleAtrial natriuretic factor and related peptide hormones.
SourceAnnu. Rev. Biochem. 60:229-255(1991).
PubMed ID1652921

4AuthorsTakei Y. Takahashi A. Watanabe T.X. Nakajima K. Sakakibara S.
TitleA novel natriuretic peptide isolated from eel cardiac ventricles.
SourceFEBS Lett. 282:317-320(1991).
PubMed ID1828035

5AuthorsSchweitz H. Vigne P. Moinier D. Frelin C. Lazdunski M.
TitleA new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps).
SourceJ. Biol. Chem. 267:13928-13932(1992).
PubMed ID1352773

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