We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00298Surfactant associated polypeptide SP-C palmitoylation sites
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00298
Description
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-C, a component of surfactant, is a highly hydrophobic peptide of 35 amino acid residues which is processed from a larger precursor protein. SP-C is post-translationally modified by the covalent attachment of two palmitoyl groups on two adjacent cysteines [1].
Last update:May 2004 / Text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Curstedt T. Johansson J. Persson P. Eklund A. Robertson B. Lowenadler B. Jornvall H. |
| Title | Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 87:2985-2989(1990). | |
| PubMed ID | 2326260 |
| 2 | Authors | Johansson J. Persson P. Lowenadler B. Robertson B. Jornvall H. Curstedt T. |
| Title | Canine hydrophobic surfactant polypeptide SP-C. A lipopeptide with one thioester-linked palmitoyl group. | |
| Source | FEBS Lett. 281:119-122(1991). | |
| PubMed ID | 2015882 |
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