PROSITE documentation PDOC00298
Surfactant associated polypeptide SP-C palmitoylation sites


Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-C, a component of surfactant, is a highly hydrophobic peptide of 35 amino acid residues which is processed from a larger precursor protein. SP-C is post-translationally modified by the covalent attachment of two palmitoyl groups on two adjacent cysteines [1].

Last update:

May 2004 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SURFACT_PALMITOYL, PS00341; Surfactant associated polypeptide SP-C palmitoylation sites  (PATTERN)


1AuthorsCurstedt T. Johansson J. Persson P. Eklund A. Robertson B. Lowenadler B. Jornvall H.
TitleHydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups.
SourceProc. Natl. Acad. Sci. U.S.A. 87:2985-2989(1990).
PubMed ID2326260

2AuthorsJohansson J. Persson P. Lowenadler B. Robertson B. Jornvall H. Curstedt T.
TitleCanine hydrophobic surfactant polypeptide SP-C. A lipopeptide with one thioester-linked palmitoyl group.
SourceFEBS Lett. 281:119-122(1991).
PubMed ID2015882

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