PROSITE documentation PDOC00298Surfactant associated polypeptide SP-C palmitoylation sites
Description
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-C, a component of surfactant, is a highly hydrophobic peptide of 35 amino acid residues which is processed from a larger precursor protein. SP-C is post-translationally modified by the covalent attachment of two palmitoyl groups on two adjacent cysteines [1].
Last update:May 2004 / Text revised.
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Technical section
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References
| 1 | Authors | Curstedt T. Johansson J. Persson P. Eklund A. Robertson B. Lowenadler B. Jornvall H. |
| Title | Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 87:2985-2989(1990). | |
| PubMed ID | 2326260 |
| 2 | Authors | Johansson J. Persson P. Lowenadler B. Robertson B. Jornvall H. Curstedt T. |
| Title | Canine hydrophobic surfactant polypeptide SP-C. A lipopeptide with one thioester-linked palmitoyl group. | |
| Source | FEBS Lett. 281:119-122(1991). | |
| PubMed ID | 2015882 |
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