PROSITE documentation PDOC00327
ATP synthase delta (OSCP) subunit signature


ATP synthase (proton-translocating ATPase) (EC [1,2] is a component of the cytoplasmic membrane of eubacteria, the inner membrane of mitochondria, and the thylakoid membrane of chloroplasts. The ATPase complex is composed of an oligomeric transmembrane sector, called CF(0), which acts as a proton channel, and a catalytic core, termed coupling factor CF(1).

One of the subunits of the ATPase complex, known as subunit delta in bacteria and chloroplasts or the Oligomycin Sensitivity Conferral Protein (OSCP) in mitochondria, seems to be part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) into CF(1) or is involved in proton conduction [3].

The different delta/OSCP subunits are proteins of approximately 200 amino-acid residues - once the transit peptide has been removed in the chloroplast and mitochondrial forms - which show only moderate sequence homology.

The signature pattern used to detect ATPase delta/OSCP subunits is based on a conserved region in the C-terminal section of these proteins.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

ATPASE_DELTA, PS00389; ATP synthase delta (OSCP) subunit signature  (PATTERN)


1AuthorsFutai M. Noumi T. Maeda M.
TitleATP synthase (H+-ATPase): results by combined biochemical and molecular biological approaches.
SourceAnnu. Rev. Biochem. 58:111-136(1989).
PubMed ID2528322

2AuthorsSenior A.E.
TitleATP synthesis by oxidative phosphorylation.
SourcePhysiol. Rev. 68:177-231(1988).
PubMed ID2892214

3AuthorsEngelbrecht S. Junge W.
TitleSubunit delta of H(+)-ATPases: at the interface between proton flow and ATP synthesis.
SourceBiochim. Biophys. Acta 1015:379-390(1990).
PubMed ID2154253

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)