PROSITE documentation PDOC00337
Prokaryotic sulfate- and thiosulfate-binding proteins signatures


Sulfate-binding protein (gene sbp or sbpA) and thiosulfate-binding protein (gene cysP) are two structurally related periplasmic bacterial proteins which specifically bind sulfate and thiosulfate and are involved in the transport systems for these nutrients [1,2].

As signature patterns for these proteins we selected two conserved regions; one located in the N-terminal region and the other in the central part of these proteins. The second pattern includes two adjacent amino acids (Ser-Gly) that, in sbp, are known to be essential for sulfate binding [3].

Last update:

October 1993 / Patterns and text revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

PROK_SULFATE_BIND_1, PS00401; Prokaryotic sulfate-binding proteins signature 1  (PATTERN)

PROK_SULFATE_BIND_2, PS00757; Prokaryotic sulfate-binding proteins signature 2  (PATTERN)


1AuthorsHryniewicz M. Sirko A. Palucha A. Boeck A. Hulanicka D.
TitleSulfate and thiosulfate transport in Escherichia coli K-12: identification of a gene encoding a novel protein involved in thiosulfate binding.
SourceJ. Bacteriol. 172:3358-3366(1990).
PubMed ID2188959

2AuthorsLaudenbach D.E. Grossman A.R.
TitleCharacterization and mutagenesis of sulfur-regulated genes in a cyanobacterium: evidence for function in sulfate transport.
SourceJ. Bacteriol. 173:2739-2750(1991).
PubMed ID1708375

3AuthorsPflugrath J.W. Quiocho F.A.
TitleThe 2 A resolution structure of the sulfate-binding protein involved in active transport in Salmonella typhimurium.
SourceJ. Mol. Biol. 200:163-180(1988).
PubMed ID3288756

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