PROSITE documentation PDOC00337Prokaryotic sulfate- and thiosulfate-binding proteins signatures
Sulfate-binding protein (gene sbp or sbpA) and thiosulfate-binding protein (gene cysP) are two structurally related periplasmic bacterial proteins which specifically bind sulfate and thiosulfate and are involved in the transport systems for these nutrients [1,2].
As signature patterns for these proteins we selected two conserved regions; one located in the N-terminal region and the other in the central part of these proteins. The second pattern includes two adjacent amino acids (Ser-Gly) that, in sbp, are known to be essential for sulfate binding [3].
Last update:October 1993 / Patterns and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Hryniewicz M. Sirko A. Palucha A. Boeck A. Hulanicka D. |
| Title | Sulfate and thiosulfate transport in Escherichia coli K-12: identification of a gene encoding a novel protein involved in thiosulfate binding. | |
| Source | J. Bacteriol. 172:3358-3366(1990). | |
| PubMed ID | 2188959 |
| 2 | Authors | Laudenbach D.E. Grossman A.R. |
| Title | Characterization and mutagenesis of sulfur-regulated genes in a cyanobacterium: evidence for function in sulfate transport. | |
| Source | J. Bacteriol. 173:2739-2750(1991). | |
| PubMed ID | 1708375 |
| 3 | Authors | Pflugrath J.W. Quiocho F.A. |
| Title | The 2 A resolution structure of the sulfate-binding protein involved in active transport in Salmonella typhimurium. | |
| Source | J. Mol. Biol. 200:163-180(1988). | |
| PubMed ID | 3288756 |
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