PROSITE documentation PDOC00350
Cereal trypsin/alpha-amylase inhibitors family signature


The seeds of cereals contain numerous serine proteases and α-amylase inhibitors. These inhibitors can be grouped into families based on structural similarities. The cereal trypsin/α-amylase inhibitor family [1,2] consists of proteins of about 120 amino acids which contain 10 cysteine residues, all of which are involved in disulfide bonds. Some of these inhibitors are specific to trypsin, others to α-amylase, and a few are bifunctional. The schematic representation of the structure of these inhibitors is shown below:

           +----------+|   +-+                      |
    *******|****      ||   | |                      |
    |          |                           |                |
    |          +---------------------------+                |
'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.

This family of proteins also includes a number of seed allergenic protein from rice [3].

Last update:

May 2004 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CEREAL_TRYP_AMYL_INH, PS00426; Cereal trypsin/alpha-amylase inhibitors family signature  (PATTERN)


1AuthorsGautier M.-F. Alary R. Joudrier P.
TitleCloning and characterization of a cDNA encoding the wheat (Triticum durum Desf.) CM16 protein.
SourcePlant Mol. Biol. 14:313-322(1990).
PubMed ID2102817

2AuthorsGarcia-Olmedo F. Salcedo G. Sanchez-Monge R. Gomez L. Royo J. Carbonero P.
Source(In) Oxford Surveys of Plant Molecular and Cell Biology, Miflin B., Ed., vol. 4, pp. 275-334, Oxford University Press, Oxford, (1987).

3AuthorsAdachi T. Izumi H. Yamada T. Tanaka K. Takeuchi S. Nakamura R. Matsuda T.
SourcePlant Mol. Biol. 21:239-248(1993).

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