PROSITE documentation PDOC00353Staphylocoagulase repeat signature
Staphylocoagulase [1,2] is an extracellular protein produced by several strains of Staphylococcus aureus and which specifically forms a complex with prothrombin. This complex named staphylothrombin can clot fibrinogen without any proteolytic cleavage of prothrombin.
The C-terminal of staphylocoagulase consists in the tandem repeat of a domain of 27 amino acids. There are from 6 to 8 of these repeats, depending on the strain of Staphylococcus aureus. The region containing these repeats is not required for the procoagulant activity.
We have derived a signature pattern specific for the 27 residues repeat of staphylocoagulase.
Last update:November 1990 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Kaida S. Miyata T. Yoshizawa Y. Kawabata S. Morita T. Igarashi H. Iwanaga S. |
| Title | Nucleotide sequence of the staphylocoagulase gene: its unique COOH-terminal 8 tandem repeats. | |
| Source | J. Biochem. 102:1177-1186(1987). | |
| PubMed ID | 3481366 |
| 2 | Authors | Kaida S. Miyata T. Yoshizawa Y. Igarashi H. Iwanaga S. |
| Title | Nucleotide and deduced amino acid sequences of staphylocoagulase gene from Staphylococcus aureus strain 213. | |
| Source | Nucleic Acids Res. 17:8871-8871(1989). | |
| PubMed ID | 2587230 |
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