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PROSITE documentation PDOC00388 |
Mismatch repair contributes to the overall fidelity of DNA replication [1]. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. The sequence of some proteins involved in mismatch repair in different organisms have been found to be evolutionary related [2,3]. One of these families is called mutS [4], it consists of:
As a signature pattern for this class of mismatch repair proteins we selected a region rich in glycine and negatively charged residues. This region is found in the C-terminal section of these proteins; about 80 residues to the C-terminal of an ATP-binding site motif 'A' (P-loop) (see <PDOC00017>).
Expert(s) to contact by email: Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Modrich P. |
Title | DNA mismatch correction. | |
Source | Annu. Rev. Biochem. 56:435-466(1987). | |
PubMed ID | 3304141 | |
DOI | 10.1146/annurev.bi.56.070187.002251 |
2 | Authors | Haber L.T. Walker G.C. |
Title | Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities. | |
Source | EMBO J. 10:2707-2715(1991). | |
PubMed ID | 1651234 |
3 | Authors | New L. Liu K. Crouse G.F. |
Title | The yeast gene MSH3 defines a new class of eukaryotic MutS homologues. | |
Source | Mol. Gen. Genet. 239:97-108(1993). | |
PubMed ID | 8510668 |
4 | Authors | Eisen J.A. |
Title | A phylogenomic study of the MutS family of proteins. | |
Source | Nucleic Acids Res. 26:4291-4300(1998). | |
PubMed ID | 9722651 |